Differentiating symptomatic Parkin mutations carriers from patients with idiopathic Parkinson's disease: Contribution of automated segmentation neuroimaging method

Bilgic B. , BAYRAM A. , Arsian A. B. , Hanagasi H. A. , Dursun B., Gurvit H. , ...More

PARKINSONISM & RELATED DISORDERS, vol.18, no.5, pp.562-566, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1016/j.parkreldis.2012.02.017
  • Page Numbers: pp.562-566


Background: Parkin (PARK2) gene mutations are the predominant cause of autosomal recessive parkinsonism. Characteristic features include: early onset symptoms with slow clinical course, good response to low doses of levodopa, and frequently treatment-induced dyskinesia. Studies using a voxel-based morphometry approach showed a decrease in the gray matter volume of the basal ganglia in mutation carriers during the symptomatic stages. A bilateral, presumably compensatory increase of basal ganglia gray matter value was recently demonstrated in asymptomatic Parkin mutation carriers. Behavioral disorders including: anxiety, psychosis, panic attacks, depression, disturbed sexual, behavioral and obsessive-compulsive disorders have been reported in these patients.