Differentiating symptomatic Parkin mutations carriers from patients with idiopathic Parkinson's disease: Contribution of automated segmentation neuroimaging method
PARKINSONISM & RELATED DISORDERS, cilt.18, sa.5, ss.562-566, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 5
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.parkreldis.2012.02.017
- Dergi Adı: PARKINSONISM & RELATED DISORDERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.562-566
- İstanbul Üniversitesi Adresli: Evet
Özet
Background: Parkin (PARK2) gene mutations are the predominant cause of autosomal recessive parkinsonism. Characteristic features include: early onset symptoms with slow clinical course, good response to low doses of levodopa, and frequently treatment-induced dyskinesia. Studies using a voxel-based morphometry approach showed a decrease in the gray matter volume of the basal ganglia in mutation carriers during the symptomatic stages. A bilateral, presumably compensatory increase of basal ganglia gray matter value was recently demonstrated in asymptomatic Parkin mutation carriers. Behavioral disorders including: anxiety, psychosis, panic attacks, depression, disturbed sexual, behavioral and obsessive-compulsive disorders have been reported in these patients.