Differentiating symptomatic Parkin mutations carriers from patients with idiopathic Parkinson's disease: Contribution of automated segmentation neuroimaging method


Bilgic B., BAYRAM A., Arsian A. B., Hanagasi H. A., Dursun B., Gurvit H., ...More

PARKINSONISM & RELATED DISORDERS, vol.18, no.5, pp.562-566, 2012 (SCI-Expanded) identifier identifier identifier

Abstract

Background: Parkin (PARK2) gene mutations are the predominant cause of autosomal recessive parkinsonism. Characteristic features include: early onset symptoms with slow clinical course, good response to low doses of levodopa, and frequently treatment-induced dyskinesia. Studies using a voxel-based morphometry approach showed a decrease in the gray matter volume of the basal ganglia in mutation carriers during the symptomatic stages. A bilateral, presumably compensatory increase of basal ganglia gray matter value was recently demonstrated in asymptomatic Parkin mutation carriers. Behavioral disorders including: anxiety, psychosis, panic attacks, depression, disturbed sexual, behavioral and obsessive-compulsive disorders have been reported in these patients.