Folic acid conjugated PAMAM-modified mesoporous silica-coated superparamagnetic iron oxide nanoparticles for potential cancer therapy


Sagir T., Huysal M., Senel M., Isik S., Burgucu N., Tabakoglu O., ...Daha Fazla

JOURNAL OF COLLOID AND INTERFACE SCIENCE, cilt.625, ss.711-721, 2022 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 625
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.jcis.2022.06.069
  • Dergi Adı: JOURNAL OF COLLOID AND INTERFACE SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Applied Science & Technology Source, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.711-721
  • Anahtar Kelimeler: Magnetic nanoparticles, Photodynamic therapy, Drug delivery, Dendrimers, Antitumor activity, DRUG-DELIVERY SYSTEMS, INDOCYANINE GREEN, PHOTODYNAMIC THERAPY, MAGNETIC NANOPARTICLES, FOLATE BINDING, DENDRIMERS, FLUORESCENCE, BIOCOMPATIBILITY, POLYMERS, RELEASE
  • İstanbul Üniversitesi Adresli: Hayır

Özet

In this study, novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery agents for photodynamic therapy applications. The surface of the magnetic nanoparticles was coated with mesoporous silica (M-MSN). The M-MSN nanoparticles were functionalized with siloxane-cored PAMAM dendrons (generation 1 to 3). The surface of the M-MSN-PAMAM nanocarriers was targeted with folic acid. Indocyanine green (ICG) a near-infrared dye was loaded in the M-MSN-PAMAM nanocarriers and the photodynamic therapy efficiency of the drug-loaded nanocarriers was evaluated on MCF-7 cells.