Folic acid conjugated PAMAM-modified mesoporous silica-coated superparamagnetic iron oxide nanoparticles for potential cancer therapy
JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol.625, pp.711-721, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 625
- Publication Date: 2022
- Doi Number: 10.1016/j.jcis.2022.06.069
- Journal Name: JOURNAL OF COLLOID AND INTERFACE SCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Applied Science & Technology Source, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
- Page Numbers: pp.711-721
- Keywords: Magnetic nanoparticles, Photodynamic therapy, Drug delivery, Dendrimers, Antitumor activity, DRUG-DELIVERY SYSTEMS, INDOCYANINE GREEN, PHOTODYNAMIC THERAPY, MAGNETIC NANOPARTICLES, FOLATE BINDING, DENDRIMERS, FLUORESCENCE, BIOCOMPATIBILITY, POLYMERS, RELEASE
- Istanbul University Affiliated: No
Abstract
In this study, novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery agents for photodynamic therapy applications. The surface of the magnetic nanoparticles was coated with mesoporous silica (M-MSN). The M-MSN nanoparticles were functionalized with siloxane-cored PAMAM dendrons (generation 1 to 3). The surface of the M-MSN-PAMAM nanocarriers was targeted with folic acid. Indocyanine green (ICG) a near-infrared dye was loaded in the M-MSN-PAMAM nanocarriers and the photodynamic therapy efficiency of the drug-loaded nanocarriers was evaluated on MCF-7 cells.