Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy
METABOLISM-CLINICAL AND EXPERIMENTAL, cilt.65, sa.10, ss.1466-1477, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 65 Sayı: 10
- Basım Tarihi: 2016
- Doi Numarası: 10.1016/j.metabol.2016.06.010
- Dergi Adı: METABOLISM-CLINICAL AND EXPERIMENTAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1466-1477
- İstanbul Üniversitesi Adresli: Evet
Özet
Background. Apoptosis contributes nephropathy pathogenesis in diabetes. However, its mechanisms still remain unclear. We examined the extent to which the angiotensin-II type 1 receptor blocker (AT1RB) irbesartan and the angiotensin converting enzyme inhibitor (ACEI) perindopril affected the apoptosis-related proteins Bcl-2, Bax, caspase-3, cytochrome-c and Ku70 in streptozotocin (STZ)-diabetic rats.