Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy
METABOLISM-CLINICAL AND EXPERIMENTAL, vol.65, no.10, pp.1466-1477, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 65 Issue: 10
- Publication Date: 2016
- Doi Number: 10.1016/j.metabol.2016.06.010
- Journal Name: METABOLISM-CLINICAL AND EXPERIMENTAL
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1466-1477
- Istanbul University Affiliated: Yes
Abstract
Background. Apoptosis contributes nephropathy pathogenesis in diabetes. However, its mechanisms still remain unclear. We examined the extent to which the angiotensin-II type 1 receptor blocker (AT1RB) irbesartan and the angiotensin converting enzyme inhibitor (ACEI) perindopril affected the apoptosis-related proteins Bcl-2, Bax, caspase-3, cytochrome-c and Ku70 in streptozotocin (STZ)-diabetic rats.