Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy


Tuncdemir M. , Ozturk M.

METABOLISM-CLINICAL AND EXPERIMENTAL, vol.65, no.10, pp.1466-1477, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 10
  • Publication Date: 2016
  • Doi Number: 10.1016/j.metabol.2016.06.010
  • Title of Journal : METABOLISM-CLINICAL AND EXPERIMENTAL
  • Page Numbers: pp.1466-1477

Abstract

Background. Apoptosis contributes nephropathy pathogenesis in diabetes. However, its mechanisms still remain unclear. We examined the extent to which the angiotensin-II type 1 receptor blocker (AT1RB) irbesartan and the angiotensin converting enzyme inhibitor (ACEI) perindopril affected the apoptosis-related proteins Bcl-2, Bax, caspase-3, cytochrome-c and Ku70 in streptozotocin (STZ)-diabetic rats.