Regulation of the Ku70 and apoptosis-related proteins in experimental diabetic nephropathy

Tuncdemir M., Ozturk M.

METABOLISM-CLINICAL AND EXPERIMENTAL, cilt.65, sa.10, ss.1466-1477, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 10
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.metabol.2016.06.010
  • Dergi Adı: METABOLISM-CLINICAL AND EXPERIMENTAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1466-1477
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background. Apoptosis contributes nephropathy pathogenesis in diabetes. However, its mechanisms still remain unclear. We examined the extent to which the angiotensin-II type 1 receptor blocker (AT1RB) irbesartan and the angiotensin converting enzyme inhibitor (ACEI) perindopril affected the apoptosis-related proteins Bcl-2, Bax, caspase-3, cytochrome-c and Ku70 in streptozotocin (STZ)-diabetic rats.