Research Information System
21.European Stroke Conference, Lisbon, Portugal, 22 - 24 May 2012, pp.651-652
BACKROUND: Stroke survivors are at
high risk of recurrent stroke, communitybased
studies show that this risk is about
30%. Recurrent strokes tend to be more
deadly than the first stroke and lead to
further neurological impairment. In this
sudy, in-hospital stroke recurrence in
a university hospital stroke unit setting
were investigated.
PATIENTS AND METHODS: Stroke
registry data of 2128 patients hospitalized
at the Istanbul Faculty of Medicine,
Department of Neurology, Edip Aktin
Stroke Unit between 1994-2007 were
evaluated. Recurent stroke was defined
as a new neurological deficit not caused
by neurological complications such as
edema, mass effect or hemorrhagic transformation
or progression of the index
event. Clinical, laboratory and neuroimaging
findings of 67 recurrent ischemic
stroke patients were compared with ischemic
stroke patients (n = 1658) without
any recurrence. Statistical methods used
were; chi-squared test for parametric
variables, t-test for continuous variables
and univariate and multivariate analysis
using SPSS version 15.0.
RESULTS: In- hospital stroke reccurence
rate was 3.9% (n = 83/2128) in
all stroke patients and %4 in ischemic
stroke (IS) patients. There were no statistically
significant differences between
IS patients with and without recurrence
in terms of demographic features, and
most traditional risk factors. Only peripheral
vascular disease frequency was significantly higher in the recurrent stroke group (p = 0.05, 95% CI = 0.98 to
5.524). Posterior circulation syndrome
(POCS) and was significantly more frequently
encountered in the recurrent
stroke group (p = 0.012).The most important
factor in determining the recurrence
of IS was large artery atherosclerosis
(LAS) (p <0.001, 95% CI = 0.062 to
0.44).
CONCLUSION: In a stroke unit where
acute stroke treatments were mostly unavailable,
a higher in-hospital stroke recurrence
rate associated with LAS in IS
patients may be indicative of the importance
of early theraputic intervention.