Optimization and Characterization of Aqueous Micellar Formulations for Ocular Delivery of an Antifungal Drug, Posaconazole

Durgun M., Kahraman E., Güngör S., Özsoy Y.

CURRENT PHARMACEUTICAL DESIGN, vol.26, no.14, pp.1543-1555, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 14
  • Publication Date: 2020
  • Doi Number: 10.2174/1381612826666200313172207
  • Journal Name: CURRENT PHARMACEUTICAL DESIGN
  • Journal Indexes: Science Citation Index Expanded, Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1543-1555
  • Keywords: Micelles, D-alpha-tocopheryl polyethylene glycol succinate (TPGS), Pluronic F127, Pluronic F68, posaconazole, antifungal agent, ocular drug delivery, antifungal therapy, POLYMERIC MICELLES, NANOPARTICLES, NANOCARRIERS, ITRACONAZOLE, STRATEGIES, CARRIERS

Abstract

Background: Topical therapy is preferred for the management of ocular fungal infections due to its superiorities which include overcoming potential systemic side effects risk of drugs, and targeting of drugs to the site of disease. However, the optimization of effective ocular formulations has always been a major challenge due to restrictions of ocular barriers and physiological conditions. Posaconazole, an antifungal and highly lipophilic agent with broad-spectrum, has been used topically as off-label in the treatment of ocular fungal infections due to its highly lipophilic character. Micellar carriers have the potential to improve the solubility of lipophilic drugs and, overcome ocular barriers.