Prognostic Value of Antithrombin Levels in COVID-19 Patients and Impact of Fresh Frozen Plasma Treatment: A Retrospective Study


Anaklı İ., Ergin Özcan P., Polat Ö., Orhun G., Alay G. H. , Tuna V., ...More

Turkish journal of haematology : official journal of Turkish Society of Haematology, vol.38, pp.15-21, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38
  • Publication Date: 2021
  • Doi Number: 10.4274/tjh.galenos.2021.2020.0695
  • Journal Name: Turkish journal of haematology : official journal of Turkish Society of Haematology
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.15-21
  • Keywords: Antithrombin, COVID-19, Fresh frozen plasma, Hypercoagulopathy, Mortality, KAPPA-B ACTIVATION

Abstract

Objective: The defective interplay between coagulation and inflammation may be the leading cause of intravascular coagulation and organ dysfunction in coronavirus disease-19 (COVID-19) patients. Abnormal coagulation profiles were reported to be associated with poor outcomes. In this study, we assessed the prognostic values of antithrombin (AT) activity levels and the impact of fresh frozen plasma (FFP) treatment on outcome.