Enhancing Nasopharyngeal Cancer Follow-up: 68Ga-Trivehexin PET/CT for Distinguishing Recurrence From Infection

Zorba D. D., Isik E. G., Arslan D. F., ŞEN C., Kuyumcu S.

Clinical Nuclear Medicine, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1097/rlu.0000000000006015
  • Dergi Adı: Clinical Nuclear Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Anahtar Kelimeler: 68Ga-Trivehexin PET/CT, head and neck SCC, infection imaging, nasopharyngeal cancer, NFSCC
  • İstanbul Üniversitesi Adresli: Evet

Özet

The role of 18F-FDG PET/CT (FDG) in detecting recurrence of nasopharyngeal squamous cell carcinoma (NFSCC) is undeniably high; however, hypermetabolism due to infection/inflammation can lead to false-positive interpretation. 68Ga-Trivehexin PET/CT (TRV-PET), a new PET imaging agent used to visualize αVβ6 integrin receptors, has shown promising results in overcoming false-positive FDG uptake in lymph node metastases in head and neck tumors. This case report compares the findings of 68Ga-Trivehexin PET/CT with 18F-FDG PET/CT, 99mTc-MDP bone scintigraphy (BS), and 99mTc-HMPAO labeled leukocyte scintigraphy (LLS) in the differential diagnosis of local recurrence/infection in a patient with a history of NFSCC.