Enhancing Nasopharyngeal Cancer Follow-up: 68Ga-Trivehexin PET/CT for Distinguishing Recurrence From Infection
Clinical Nuclear Medicine, cilt.51, sa.3, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1097/rlu.0000000000006015
- Dergi Adı: Clinical Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Anahtar Kelimeler: 68Ga-Trivehexin PET/CT, head and neck SCC, infection imaging, nasopharyngeal cancer, NFSCC
- İstanbul Üniversitesi Adresli: Evet
Özet
The role of 18F-FDG PET/CT (FDG) in detecting recurrence of nasopharyngeal squamous cell carcinoma (NFSCC) is undeniably high; however, hypermetabolism due to infection/inflammation can lead to false-positive interpretation. 68Ga-Trivehexin PET/CT (TRV-PET), a new PET imaging agent used to visualize αVβ6 integrin receptors, has shown promising results in overcoming false-positive FDG uptake in lymph node metastases in head and neck tumors. This case report compares the findings of 68Ga-Trivehexin PET/CT with 18F-FDG PET/CT, 99mTc-MDP bone scintigraphy (BS), and 99mTc-HMPAO labeled leukocyte scintigraphy (LLS) in the differential diagnosis of local recurrence/infection in a patient with a history of NFSCC.