Neuroleptic Malignant Syndrome Due to Risperidone Treatment in a Child With Joubert Syndrome

Vurucu S., Congologlu A., ALTUN BİNGÖL D., Unay B., Akin R.

JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, vol.101, no.3, pp.273-275, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 101 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1016/s0027-9684(15)30858-0
  • Journal Name: JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.273-275
  • Keywords: central nervous system disorders, neurology, drugs, RISK-FACTORS
  • Istanbul University Affiliated: No

Abstract

Joubert syndrome is a rare autosomal recessive disease characterized by hypotonia, ataxia, episodic hyperpnea, psychomotor retardation, abnormal ocular movements, cerebellar vermian hypoplasia, and molar tooth sign on magnetic resonance imaging. Neuroleptic malignant syndrome is an uncommon and potentially fatal idiosynchratic reaction of antipsychotic drugs, in which the clinical scenario encompass muscular rigidity, hyperthermia, autonomic dysfunction, altered consciousness, high creatinine phosphokinase levels, and leukocytosis. This report describes a case of neuroleptic malignant syndrome due to risperidone in a child with Joubert syndrome.