Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of gastrointestinal tractus. GISTs originate in stomach (60%), in small bowel (60%), in colon and rectum (5-10%), and in esophageus, omentum, mesenter and retroperitoneum at smaller rates (1%). At the time of diagnosis, approximately half of the cases are observed as being metastasised, and they mostly make metastasis to liver (50-60%) and peritoneum (20-43%). However, bone and lymph node metastasis in GISTs have been quite rarely reported in the literature. In our case, 22 cm sized GIST was detected in stomach and completely removed by a surgical operation. Due to large size of the non-metastasised case mass (>10 cm) and increased mitotic index (>5/10 hpf), it was considered as having high risk and imatinib therapy was initiated. At the 6th year of imatinib therapy, the patient applied to hospital with the complaints of abdominal pain and swelling, and common metastases were detected at liver, peritoneum, bone and lymph nodes. In this study, the literature was reviewed due to the case with GIST which was completely removed and manifested with atypical metastases at the 6th year of imatinib therapy