Genetic alterations in human prostate cancer: A review of current literature

Ozen M., Pathak S.

ANTICANCER RESEARCH, vol.20, pp.1905-1912, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 20
  • Publication Date: 2000
  • Journal Name: ANTICANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1905-1912
  • Istanbul University Affiliated: No

Abstract

We review the literature dealing with genetic alterations in human prostate cancer. We also discuss genetic predisposition and the roles of various proto-oncogenes and tumor-suppressor genes in prostate cancer initiation, progression, and metastasis. The role of telomere dynamics in prostate cancer metastasis and the induction of apoptosis is also briefly discussed.