The music-inspired metaheuristic method, called harmony search (HS), is an effective tool in optimization of engineering design problems. HS has been applied for the optimum design of reinforced concrete (RC) members so as to find the best solution, balancing the usability of the design and economy. In this chapter, the optimum design of RC members is presented after optimization of RC members. Then, HS-based optimization applications, such as RC slender columns, RC shear walls, and post-tensioned RC axially symmetric cylindrical walls, are also discussed. The HS-based methods are feasible in finding the optimum design in such problems.