Effects of granulocyte macrophage colony stimulating factor on random flap healing and immune profile in rats with impaired wound healing by glucocorticoids


Ergun S., Kyran B., Su O., Bilgic B. , Ypsever H., Kucuk M.

ANNALS OF PLASTIC SURGERY, cilt.52, sa.1, ss.80-88, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Konu: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1097/01.sap.0000096449.71981.1b
  • Dergi Adı: ANNALS OF PLASTIC SURGERY
  • Sayfa Sayıları: ss.80-88

Özet

Wound healing involves inflammation, cell proliferation, matrix deposition, and tissue remodeling. Priming the tissue to be incised with proinflammatory cytokines offers a new approach to wound healing. This has been studied mostly in incisional wounds till now. This study was designed to investigate the role of granulocyte macrophage colony stimulating factor (GM-CSF) priming of planned incision lines in random flaps in rats with impaired wound healing due to glucocorticoid administration, and immune profiles of rats were also evaluated.