Protective effects of vitamins A and E pretreatment in venous ischemia/reperfusion injury

Bilgin-Karabulut A., Ademoglu E., AYDIN İ., Erer M., Gokkusu C.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY, vol.17, no.6, pp.425-429, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2001
  • Doi Number: 10.1055/s-2001-16356
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.425-429
  • Istanbul University Affiliated: Yes


It has been suggested that venous ischemia is more injurious to tissue viability than is arterial ischemia of equivalent duration. The precise mechanism of tissue damage due to venous ischemia is still not well-determined. Current research has shown that it is multifactorial, and that lipid peroxides, prostanoid metabolism, and a free radical mechanism are the major contributors. Vitamins A and E are lipid-soluble vitamins that have been suggested to be successful in the treatment of arterial ischemia/reperfusion injury due to their antioxidant properties. In the present study, the authors examined the protective effects of vitamins A and E pretreatment on reperfusion injury induced by venous occlusion of rat epigastric island flaps based on an epigastric artery and vein pedicle.