Radio labelling of peptides for PET, SPECT and therapeutic applications using a fully automated disposable cassette system


Petrik M., Knetsch P. A. , Knopp R., Imperato G., Ocak M. , von Guggenberg E., ...Daha Fazla

NUCLEAR MEDICINE COMMUNICATIONS, cilt.32, ss.887-895, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 10
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1097/mnm.0b013e3283497188
  • Dergi Adı: NUCLEAR MEDICINE COMMUNICATIONS
  • Sayfa Sayıları: ss.887-895

Özet

Objectives Radio labelled somatostatin analogues have found wide clinical use in nuclear medicine for both diagnostic and therapeutic applications. Here, we describe the development of a fully automated synthesis system allowing radiolabelling of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-derivatized peptides with (68)Ga/(111)In/(177)Lu and (90)Y, meeting radiation safety and. pharmaceutical requirements.