Radio labelling of peptides for PET, SPECT and therapeutic applications using a fully automated disposable cassette system


Petrik M., Knetsch P. A., Knopp R., Imperato G., Ocak M., von Guggenberg E., ...More

NUCLEAR MEDICINE COMMUNICATIONS, vol.32, no.10, pp.887-895, 2011 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 32 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1097/mnm.0b013e3283497188
  • Journal Name: NUCLEAR MEDICINE COMMUNICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.887-895
  • Keywords: automation, diagnostics and therapy, radiolabelled peptides, radiopharmaceuticals, RGD PEPTIDES, RECEPTOR, ANALOGS, RADIOPHARMACEUTICALS, IN-111, GA-68
  • Istanbul University Affiliated: Yes

Abstract

Objectives Radio labelled somatostatin analogues have found wide clinical use in nuclear medicine for both diagnostic and therapeutic applications. Here, we describe the development of a fully automated synthesis system allowing radiolabelling of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-derivatized peptides with (68)Ga/(111)In/(177)Lu and (90)Y, meeting radiation safety and. pharmaceutical requirements.