Radio labelling of peptides for PET, SPECT and therapeutic applications using a fully automated disposable cassette system


Petrik M., Knetsch P. A. , Knopp R., Imperato G., Ocak M. , von Guggenberg E., ...More

NUCLEAR MEDICINE COMMUNICATIONS, vol.32, no.10, pp.887-895, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1097/mnm.0b013e3283497188
  • Title of Journal : NUCLEAR MEDICINE COMMUNICATIONS
  • Page Numbers: pp.887-895

Abstract

Objectives Radio labelled somatostatin analogues have found wide clinical use in nuclear medicine for both diagnostic and therapeutic applications. Here, we describe the development of a fully automated synthesis system allowing radiolabelling of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-derivatized peptides with (68)Ga/(111)In/(177)Lu and (90)Y, meeting radiation safety and. pharmaceutical requirements.