Radio labelling of peptides for PET, SPECT and therapeutic applications using a fully automated disposable cassette system

Petrik M., Knetsch P. A., Knopp R., Imperato G., Ocak M., von Guggenberg E., ...Daha Fazla

NUCLEAR MEDICINE COMMUNICATIONS, cilt.32, sa.10, ss.887-895, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 10
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1097/mnm.0b013e3283497188
  • Dergi Adı: NUCLEAR MEDICINE COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.887-895
  • Anahtar Kelimeler: automation, diagnostics and therapy, radiolabelled peptides, radiopharmaceuticals, RGD PEPTIDES, RECEPTOR, ANALOGS, RADIOPHARMACEUTICALS, IN-111, GA-68
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives Radio labelled somatostatin analogues have found wide clinical use in nuclear medicine for both diagnostic and therapeutic applications. Here, we describe the development of a fully automated synthesis system allowing radiolabelling of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-derivatized peptides with (68)Ga/(111)In/(177)Lu and (90)Y, meeting radiation safety and. pharmaceutical requirements.