Paecilomyces variotii central nervous system infection in a patient with cancer

Kantarcioglu A., Hatemi G., Yucel A., De Hoog G., Mandel N.

MYCOSES, vol.46, pp.45-50, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1439-0507.2003.00837.x
  • Journal Name: MYCOSES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.45-50
  • Istanbul University Affiliated: No


Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through beta-tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5-fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.