The promising role of muse cells in regenerative medicine: Mechanisms, applications, and future directions

Rajabi A., Akbarzadeh S., Tayefeh-Gholami S., Bonyadi M.

Life Sciences, vol.382, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 382
  • Publication Date: 2025
  • Doi Number: 10.1016/j.lfs.2025.124024
  • Journal Name: Life Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, Veterinary Science Database
  • Keywords: Cell-based therapies, Multilineage-differentiating stress-enduring cells, Muse cells, Regenerative medicine, Stem cells
  • Istanbul University Affiliated: No

Abstract

Over the past several years, a unique type of stem cell—called Muse (multilineage-differentiating stress-enduring) cells—has garnered increasing attention for its potential in regenerative medicine. Naturally present in the body, Muse cells exhibit remarkable traits, including stress resistance, self-renewal capability, and the ability to transform into a wide range of cell types. Unlike many conventional stem cells, they can repair damaged tissues without forming tumors or eliciting significant immune rejection. This review explores the distinctive biological identity of Muse cells, their molecular mechanisms, and their growing therapeutic potential in treating challenging conditions such as stroke, myocardial infarction, osteoarthritis, and radiation-induced intestinal injury.