Immunological tests and their interpretation in uveitis.

Rathinam S. R., Tugal-Tutkun I., Agarwal M., Rajesh V., Egriparmak M., Patnaik G.

Indian journal of ophthalmology, cilt.68, ss.1737-1748, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4103/ijo.ijo_570_20
  • Dergi Adı: Indian journal of ophthalmology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1737-1748
  • Anahtar Kelimeler: Infectious, investigations, non-infectious, novel infections, uveitis, ANTIBODY-ASSOCIATED VASCULITIS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, TOXOPLASMA-GONDII INFECTION, WEGENERS-GRANULOMATOSIS, TUBERCULOSIS INFECTION, ANTINUCLEAR ANTIBODIES, SEROLOGICAL DIAGNOSIS, RHEUMATOID-FACTOR, CLINICAL UTILITY, SYPHILIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Uveitis is a complex disorder including both infectious and non-infectious etiologies. Clinical diagnosis is a challenge because many diseases share common clinical signs. Laboratory support is crucial for confirming the clinical diagnosis. Laboratory diagnosis includes direct tests and indirect tests. For example smear, culture, and molecular diagnostics demonstrate the pathogens, hence they are direct tests. Immunologic tests employ an antigen to detect presence of antibodies to a pathogen, or an antibody to detect the presence of an antigen, of the pathogen in the specimens. The immunological tests used in laboratories are made by producing artificial antibodies that exactly "match" the pathogen in question. When these antibodies come into contact with a sample they bind to the matching pathogen if found in the sample. Hence they are grouped under indirect evidence. There are several investigations in uveitis to reach the confirmed diagnosis including microbiological, immunological, imaging and molecular diagnostic testing. In this section we will discuss immunological investigations of infectious and non-infectious uveitis.