Clinical comparison of anti-MuSK- vs anti-AChR-positive and seronegative myasthenia gravis

Deymeer F. , GUNGOR-TUNCER O., Yilmaz V. , Parman Y. , SERDAROGLU P., OZDEMIR C., ...Daha Fazla

NEUROLOGY, cilt.68, ss.609-611, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier


We compared 65 anti-acetylcholine receptor (AChR)-negative myasthenia gravis (MG) patients, including 32 anti-muscle-specific tyrosine kinase (MuSK)-positive (49%) and 33 anti-MuSK-negative (seronegative) (51%) patients, with 161 anti-AChR-positive MG patients. The anti-MuSK-positive group had a higher frequency of bulbar involvement and respiratory crises. The seronegative group was in between the anti-MuSK positive and the anti-AChR positive groups, being closer to the latter, with regard to the severity of the disease. At the end of follow-up, the outcome of the anti-MuSK-positive patients was not different from that of the anti-AChR-positive patients, although their maintenance corticosteroid dose was higher. The seronegative patients had better outcome than the other two groups.