Clinicopathologic characteristics and prognostic factors in patients with male breast cancer: A single tertiary center experience
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, vol.19, no.7, pp.1887-1892, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 19 Issue: 7
- Publication Date: 2023
- Doi Number: 10.4103/jcrt.jcrt_243_22
- Journal Name: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
- Page Numbers: pp.1887-1892
- Keywords: BRCA mutation, male breast cancer, prognosis, survival
- Istanbul University Affiliated: Yes
Abstract
Background:The goal of this study was to assess the clinicopathologic characteristics and prognostic variables in men with breast cancer (BC).Methods:Clinical features, pathological characteristics, stage at diagnosis, and therapy data were noted. Survival analysis was performed using the log-rank technique and Cox regression model.Results:Eighty patients were included in the study. In 31% of the individuals, BRCA (BReast CAncer genes 1 and 2) mutations were identified. The estrogen receptor (ER) positivity ratio was 93.6%, whereas the progesterone receptor (PR) positivity ratio was 74.4%. In 16.9% of the cases, HER2 overexpression was found. The median survival time was 120.9 months (70.3-171.5), and the five-year overall survival (OS) ratio was 74.9%. In univariate analysis, BRCA mutation status had no effect on OS (P = 0.50). CA15-3 levels (P = 0.03) at diagnosis and history of smoking (P = 0.03) were significantly linked with OS. However, the multivariate analysis could not confirm these results.Conclusions:We found that BRCA mutation, body mass index, a history of smoking, and alcohol consumption did not affect the OS in this research.