Simultaneous determination of medazepam and hyoscine butylbromide in tablets by second-derivative ultraviolet spectrometry
FARMACO, cilt.53, sa.1, ss.62-64, 1998 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 1
- Basım Tarihi: 1998
- Doi Numarası: 10.1016/s0014-827x(97)00008-6
- Dergi Adı: FARMACO
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.62-64
- İstanbul Üniversitesi Adresli: Hayır
Özet
A second-derivative UV spectrophotometric method for the simultaneous determination of medazepam and hyoscine butylbromide in sugar-coated tablets without prior separation is described. In the derivative spectrophotometric determination of these drugs, calibration graphs were obtained by plotting peak-trough amplitudes at 252.6 and 264.8 nm versus concentration of medazepam and zero-crossing amplitude at 212.5 nm versus concentration of hyoscine butylbromide. The relative standard deviation of the method was found to be +/-0.56% for medazepam and +/-0.08% for hyoscine butylbromide. This method has been successfully applied to tablets containing medazepam and hyoscine butylbromide. (C) 1998 Elsevier Science S.A.