EVALUATION OF PTEN AND PI3K/AKT EXPRESSIONS IN STANOZOLOL-TREATED RAT KIDNEYS

Kotil T., SEVİM Ç., Kara M.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.26650/iuitfd.2022.909985
  • Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Keywords: Stanozolol, Kidney, PTEN, PI3K, Akt1, ANDROGENIC STEROIDS, MEDIATED APOPTOSIS, SEVERE CHOLESTASIS, ANABOLIC-STEROIDS, PHYSICAL-ACTIVITY, OXIDATIVE STRESS, RENAL-FAILURE, NANDROLONE, PHOSPHORYLATION, SUPPLEMENTS
  • Istanbul University Affiliated: Yes

Abstract

Objective: Stanozolol is an anabolic androgenic steroid (MS) that is widely used by teenagers and athletes in bodybuilding, sports, and athletics. The potential effects of stanozolol in kidney functions have not been defined. In this study we investigated the expression of tumor suppressor protein phosphatase and tensin homolog (Pten) and mRNA levels of phosphatidylinositol 4,5-bisphosphate 3 kinase (Pi3k) and the protein kinase B (Akt1) signaling pathway in rat kidneys treated by stanozolol.