Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease
BRITISH JOURNAL OF RHEUMATOLOGY, cilt.35, sa.11, ss.1178-1180, 1996 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 11
- Basım Tarihi: 1996
- Dergi Adı: BRITISH JOURNAL OF RHEUMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1178-1180
- Anahtar Kelimeler: Behcet's disease, factor V gene mutation, activated protein C resistance, deep vein thrombosis, vasculitis, ACTIVATED PROTEIN-C, RESISTANCE, MANIFESTATIONS, DEFICIENCY
- İstanbul Üniversitesi Adresli: Evet
Özet
We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.