Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease

GUL A., OZBEK U., Inanc M., KONICE M., OZCELIK T.

BRITISH JOURNAL OF RHEUMATOLOGY, cilt.35, sa.11, ss.1178-1180, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 11
  • Basım Tarihi: 1996
  • Dergi Adı: BRITISH JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1178-1180
  • Anahtar Kelimeler: Behcet's disease, factor V gene mutation, activated protein C resistance, deep vein thrombosis, vasculitis, ACTIVATED PROTEIN-C, RESISTANCE, MANIFESTATIONS, DEFICIENCY
  • İstanbul Üniversitesi Adresli: Evet

Özet

We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.