Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease


GUL A. , OZBEK U. , Inanc M. , KONICE M. , OZCELIK T.

BRITISH JOURNAL OF RHEUMATOLOGY, vol.35, no.11, pp.1178-1180, 1996 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 11
  • Publication Date: 1996
  • Title of Journal : BRITISH JOURNAL OF RHEUMATOLOGY
  • Page Numbers: pp.1178-1180

Abstract

We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behcet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.