Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies


Demirkan A., Lahti J., Direk N. , Viktorin A., Lunetta K. L. , Terracciano A., ...Daha Fazla

PSYCHOLOGICAL MEDICINE, cilt.46, sa.8, ss.1613-1623, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Konu: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1017/s0033291715002081
  • Dergi Adı: PSYCHOLOGICAL MEDICINE
  • Sayfa Sayıları: ss.1613-1623

Özet

Background. Major depressive disorder (MDD) is moderately heritable, however genome-wide association studies (GWAS) for MDD, as well as for related continuous outcomes, have not shown consistent results. Attempts to elucidate the genetic basis of MDD may be hindered by heterogeneity in diagnosis. The Center for Epidemiological Studies Depression (CES-D) scale provides a widely used tool for measuring depressive symptoms clustered in four different domains which can be combined together into a total score but also can be analysed as separate symptom domains.