Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies

Demirkan, A.; Lahti, J.; Direk, Neşe; Viktorin, A.; Lunetta, K.; Terracciano, A.; Nalls, M.; Tanaka, T.; Hek, K.; Fornage, M.; Wellmann, J.; Cornelis, M.; Ollila, H.; Yu, L.; Smith, J.; Pilling, L.; Isaacs, A.; Palotie, A.; Zhuang, W.; Zonderman, A.; Faul, J.; Sutin, A.; Meirelles, O.; Mulas, A.; Hofman, A.; Uitterlinden, A.; Rivadeneira, F.; Perola, M.; Zhao, W.; Salomaa, V.; Yaffe, K.; Luik, A.; Liu, Y.; Ding, J.; Lichtenstein, P.; Landen, M.; Widen, E.; Weir, D.; Llewellyn, D.; Murray, A.; Kardia, S.; Eriksson, J.; Koenen, K.; Magnusson, P.; Ferrucci, L.; Mosley, T.; Cucca, F.; Oostra, B.; Bennett, D.; Paunio, T.; Berger, K.; Harris, T.; Pedersen, N.; Murabito, J.; Tiemeier, H.; van Duijn, C.; Raeikkoenen, K.

doi:10.1017/s0033291715002081

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies

Atıf İçin Kopyala

Demirkan A., Lahti J., Direk N., Viktorin A., Lunetta K. L., Terracciano A., ...Daha Fazla

PSYCHOLOGICAL MEDICINE, cilt.46, sa.8, ss.1613-1623, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 46 Sayı: 8
Basım Tarihi: 2016
Doi Numarası: 10.1017/s0033291715002081
Dergi Adı: PSYCHOLOGICAL MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
Sayfa Sayıları: ss.1613-1623
Anahtar Kelimeler: Genome-wide association studies, major depressive disorder, meta-analyses, GENETIC-FACTORS, RISK-FACTORS, MELATONIN, DESIGN, INDIVIDUALS, SYMPTOMS, RECEPTOR, HEALTH, MEMORY, CHARGE
İstanbul Üniversitesi Adresli: Hayır

Özet

Background. Major depressive disorder (MDD) is moderately heritable, however genome-wide association studies (GWAS) for MDD, as well as for related continuous outcomes, have not shown consistent results. Attempts to elucidate the genetic basis of MDD may be hindered by heterogeneity in diagnosis. The Center for Epidemiological Studies Depression (CES-D) scale provides a widely used tool for measuring depressive symptoms clustered in four different domains which can be combined together into a total score but also can be analysed as separate symptom domains.