Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas.

Gazioglu N., Erensoy N., Kadioglu P., Sayıtıoglu M., Ersoy I. H., Hatımaz O., ...Daha Fazla

Medical science monitor : international medical journal of experimental and clinical research, cilt.13, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13
  • Basım Tarihi: 2007
  • Dergi Adı: Medical science monitor : international medical journal of experimental and clinical research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: pituitary adenoma, cyclin D1, polymorphism, immunohistochemistry, SQUAMOUS-CELL CARCINOMA, EXPRESSION, POLYMORPHISM, CCND1, GENE, HEAD, NECK
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The cyclin D1 gene (CCND1) is a proto-oncogene playing a critical role in the transition through the G1 ot the S phase of the cell cyle and is overexpressed in many tumors. G870A plymorphism at the exon4/intron4 splicing region of the CCND1 gene may play a role in pituitary tumorigenesis and invasiveness. The objective of this study was to examine CCND1 polymorphism i patients with different types sporadic pituitary adenomas.