Protective effect of melatonin and carnosine against radiation induced kidney injury

TÜRKYILMAZ İ. B., Us H., Sezen Us A., Karabulut-Bulan O., YANARDAĞ R.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.331, sa.9, ss.3551-3561, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 331 Sayı: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s10967-022-08419-6
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Analytical Abstracts, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, EMBASE, Food Science & Technology Abstracts, INSPEC, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.3551-3561
  • Anahtar Kelimeler: Irradiation, Melatonin, Carnosine, Kidney damage, Oxidative stress, Free radical, OXIDATIVE STRESS, GAMMA-RADIATION, RENAL INJURY, ANTIOXIDANT, DAMAGE, NEPHROTOXICITY, PARAOXONASE, TISSUE, RATS, MITOCHONDRIA
  • İstanbul Üniversitesi Adresli: Evet

Özet

We designed this study to determine possible protective roles of melatonin and carnosine on radiation. Wistar albino rats were divided to five groups. Melatonin, carnosine and combinated version were injected to Group III, IV and V every 48 h in a week. Group II, III, IV and V were exposed to 8 Gy gamma radiation dose arranged for whole-body one hour later second injection. Degenerative and biochemical changes were determined in radiation group as compared to control group. Administration of melatonin, carnosine and their combination ameliorated these parameters. We can conclude melatonin, carnosine and their combination protect kidney against radiation.