Protective effect of melatonin and carnosine against radiation induced kidney injury

TÜRKYILMAZ İ. B., Us H., Sezen Us A., Karabulut-Bulan O., YANARDAĞ R.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.331, no.9, pp.3551-3561, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 331 Issue: 9
  • Publication Date: 2022
  • Doi Number: 10.1007/s10967-022-08419-6
  • Journal Name: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Analytical Abstracts, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, EMBASE, Food Science & Technology Abstracts, INSPEC, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.3551-3561
  • Keywords: Irradiation, Melatonin, Carnosine, Kidney damage, Oxidative stress, Free radical, OXIDATIVE STRESS, GAMMA-RADIATION, RENAL INJURY, ANTIOXIDANT, DAMAGE, NEPHROTOXICITY, PARAOXONASE, TISSUE, RATS, MITOCHONDRIA
  • Istanbul University Affiliated: Yes

Abstract

We designed this study to determine possible protective roles of melatonin and carnosine on radiation. Wistar albino rats were divided to five groups. Melatonin, carnosine and combinated version were injected to Group III, IV and V every 48 h in a week. Group II, III, IV and V were exposed to 8 Gy gamma radiation dose arranged for whole-body one hour later second injection. Degenerative and biochemical changes were determined in radiation group as compared to control group. Administration of melatonin, carnosine and their combination ameliorated these parameters. We can conclude melatonin, carnosine and their combination protect kidney against radiation.