Plasma viscosity in female patients with hypothyroidism: Effects of oxidative stress and cholesterol

Konukoglu D., Ercan M., Hatemi H.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, vol.27, no.2, pp.107-113, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2002
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.107-113
  • Istanbul University Affiliated: No


Hypothyroidism is associated with atherosclerotic events, however, the mechanism is unclear. We investigated the effects of oxidative stress and cholesterol on plasma viscosity in female patients with hypothyroidism (n=20; mean age: 45.5+/-5.5 years) at baseline and after L-thyroxine replacement therapy (average daily dose being 0.1 to 0.15 mg). Two blood samples were taken after 2.3+/-1.2 months. In hypothyroid state plasma viscosity and thiobarbituric acid reactive substance (TBARS; marker of oxidative stress were significantly higher (p<0.001 and p<0.001), and plasma protein thiol (antioxidants) levels were significantly lower (p<0.001) than in the healthy state (female; n=15). After L-thyroxine replacement therapy, patients reached to euthyroid state. In this state, the levels of plasma viscosity and TBARS were decreased (p<0.001 and p<0.001), and protein thiol levels were significantly elevated (p<0.001). There was a significant correlation between plasma cholesterol and viscosity (r=0.64, p<0.001), as well as plasma protein thiol (r=-0.59, p<0.001) in the patients. The correlation between viscosity and TBARS was weak (r=0.29, p<0.01).