Extraction socket healing in rats treated with bisphosphonate: Animal model for bisphosphonate related osteonecrosis of jaws in multiple myeloma patients


Ali-Erdem M., Burak-Cankaya A., Cemil-Isler S., Demircan S., Soluk M., Kasapoglu C., ...More

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, vol.16, no.7, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 7
  • Publication Date: 2011
  • Doi Number: 10.4317/medoral.17150
  • Journal Name: MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Bisphosphonate, osteonecrosis, extraction socket, rat, BONE METASTASES, ZOLEDRONIC ACID, PREVENTION
  • Istanbul University Affiliated: Yes

Abstract

Aim: The aim of this study is to replicate both clinical and histological presentation of bisphosphonate induced osteonecrosis of the jaws (BONJ) in an animal model of the disease state. Successful recapitulation of a BONJ-like indication in an animal model will be useful for studying pathogenesis, as well as prevention and treatment strategies for BONJ.