Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term

Uzum, AYŞE; Salman, Serpil; Telci, AYŞE; Boztepe, Harika; Tanakol, Refik; Alagol, Faruk; Ozbey, Nese

doi:10.1530/eje-10-0591

Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term

Uzum A. K., Salman S., Telci A. G. S., Boztepe H., Tanakol R., Alagol F., ...Daha Fazla

EUROPEAN JOURNAL OF ENDOCRINOLOGY, cilt.163, sa.5, ss.825-831, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 163 Sayı: 5
Basım Tarihi: 2010
Doi Numarası: 10.1530/eje-10-0591
Dergi Adı: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.825-831
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Fibroblast growth factor 23 (FGF23), a phosphatonin, inhibits renal phosphate reabsorption and suppresses 1-alpha hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women and to compare the FGF23 concentrations of vitamin D-deficient patients with healthy subjects and patients with genetically determined hypophosphatemic rachitis.