Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term
EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol.163, no.5, pp.825-831, 2010 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 163 Issue: 5
- Publication Date: 2010
- Doi Number: 10.1530/eje-10-0591
- Journal Name: EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.825-831
- Istanbul University Affiliated: Yes
Abstract
Objective: Fibroblast growth factor 23 (FGF23), a phosphatonin, inhibits renal phosphate reabsorption and suppresses 1-alpha hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women and to compare the FGF23 concentrations of vitamin D-deficient patients with healthy subjects and patients with genetically determined hypophosphatemic rachitis.