Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term


Uzum A. K. , Salman S., Telci A. G. S. , Boztepe H., Tanakol R., Alagol F., ...More

EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol.163, no.5, pp.825-831, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 163 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1530/eje-10-0591
  • Title of Journal : EUROPEAN JOURNAL OF ENDOCRINOLOGY
  • Page Numbers: pp.825-831

Abstract

Objective: Fibroblast growth factor 23 (FGF23), a phosphatonin, inhibits renal phosphate reabsorption and suppresses 1-alpha hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women and to compare the FGF23 concentrations of vitamin D-deficient patients with healthy subjects and patients with genetically determined hypophosphatemic rachitis.