Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term

Uzum, Ayşe; Salman, Serpil; Telci, Ayşe; Boztepe, Harika; Tanakol, Refik; Alagol, Faruk; Ozbey, Nese

doi:10.1530/eje-10-0591

Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term

Uzum A. K. , Salman S., Telci A. G. S. , Boztepe H., Tanakol R., Alagol F., ...More

EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol.163, no.5, pp.825-831, 2010 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 163 Issue: 5
Publication Date: 2010
Doi Number: 10.1530/eje-10-0591
Title of Journal : EUROPEAN JOURNAL OF ENDOCRINOLOGY
Page Numbers: pp.825-831

Abstract

Objective: Fibroblast growth factor 23 (FGF23), a phosphatonin, inhibits renal phosphate reabsorption and suppresses 1-alpha hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women and to compare the FGF23 concentrations of vitamin D-deficient patients with healthy subjects and patients with genetically determined hypophosphatemic rachitis.