Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis


Acar L., atalan N., Karagedik E. H., Ergen A.

BALKAN MEDICAL JOURNAL, vol.35, no.1, pp.30-35, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.4274/balkanmedj.2017.0246
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.30-35
  • Keywords: Sepsis, polymorphism, tumor necrosis factor-alpha, NF-kappa B, NFKB1 PROMOTER POLYMORPHISM, INTERLEUKIN-6 PLASMA-LEVELS, TNF-ALPHA, SEPTIC SHOCK, ASSOCIATION, MORTALITY, SUSCEPTIBILITY, NF-KAPPA-B1, CYTOKINES, CHILDREN
  • Istanbul University Affiliated: Yes

Abstract

Background: The humoral system is activated and various cytokines are released due to infections in tissues and traumatic damage. Nuclear factor-kappa B dimers are encoded by nuclear factor-kappa B genes and regulate transcription of several crucial proteins of inflammation such as tumour necrosis factor-alpha.