Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells

Coban N., GEYIK F., Yıldırım O., UNALTUNA N. E.

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, vol.45, no.2, pp.118-125, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.5543/tkda.2016.82389
  • Journal Name: TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.118-125
  • Keywords: AMPK, atherosclerosis, LASS5, ceramide, siRNA, NITRIC-OXIDE SYNTHASE, INSULIN-RESISTANCE, RISK-FACTORS, INHIBITION, SPHINGOLIPIDS, ACTIVATION, MUSCLE
  • Istanbul University Affiliated: Yes

Abstract

Objective: Ceramide, the backbone of sphingolipids, is the key component affecting atherosclerotic changes through its important second-messenger role. Previous studies have demonstrated protective role of AMP-activated protein kinase (AMPK) genes in regulating atherosclerosis and hypertension. Ceramide synthase 5 (LASS5 or CERS5) gene has function in de novo synthesis of ceramide, and has indirect effect on AMPK gene. Aim of the present study was to identify role of LASS5 gene in atherosclerosis.