Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer

Demokan S., SÜOĞLU Y. H., Demir D., Gözeler M., Dalay N.

ANNALS OF ONCOLOGY, vol.17, no.6, pp.995-999, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1093/annonc/mdl048
  • Journal Name: ANNALS OF ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.995-999
  • Keywords: methylation, hMLH1, hMSH2, microsatellite instability, head and neck cancer, SQUAMOUS-CELL CARCINOMA, PROMOTER HYPERMETHYLATION, HMLH1 PROMOTER, PROTEIN EXPRESSION, HMSH2, INACTIVATION, PHENOTYPE, FREQUENCY, TUMORS, MLH1
  • Istanbul University Affiliated: Yes

Abstract

Background: Methylation in the promoter region of the DNA mismatch repair genes hMLH1 and hMSH2 and microsatellite instability at three loci were analyzed in the tumor tissue from patients with head and neck cancer.