The Role of <i>PON1</i> Variants in Disease Susceptibility in a Turkish Population.


Abudayyak M., Boran T., Tukel R., Oztas E. , Özhan G.

Global medical genetics, vol.7, pp.41-46, 2020 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2020
  • Doi Number: 10.1055/s-0040-1715568
  • Title of Journal : Global medical genetics
  • Page Numbers: pp.41-46
  • Keywords: paraoxonase-1, hypothyroidism, pancreatitis, SERUM PARAOXONASE ACTIVITY, LOW-DENSITY-LIPOPROTEIN, CORONARY-ARTERY-DISEASE, OXIDATIVE STRESS, GENE POLYMORPHISMS, ANTIOXIDANT STATUS, INCREASED RISK, ASSOCIATION, HYPOTHYROIDISM, CANCER

Abstract

Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. PON1 genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 G allele had a two-fold risk of developing hypothyroidism. A weak association was found between rs854560 T allele and pancreatitis. The results were preliminary. Further studies with a larger number and detailed biochemical parameters are needed.