Expression Patterns of miRNA in the Experimental Autoimmune Encephalomyelitis (EAE)/MS Model Treated With Oenothera biennis Oil

Demirci H., Guleken Z., SELEK Ş., Dogan N., Yuce B., Teloglu E. S., ...Daha Fazla

Acta Neurologica Scandinavica, cilt.2025, sa.1, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2025 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1155/ane/3001118
  • Dergi Adı: Acta Neurologica Scandinavica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
  • Anahtar Kelimeler: experimental autoimmune encephalomyelitis (EAE), microRNA, miRNA array, Oenothera biennis (O. biennis)
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Dysregulation of microRNA expression emerges as a crucial factor in the pathogenesis of autoimmune diseases, and their importance in modulating immune responses and disease progression is evident. Methods: This study investigated the expression patterns of miRNAs in the brain tissues of C57BL/6J mice using the experimental autoimmune encephalomyelitis (EAE) model, which mimics multiple sclerosis (MS). The model was treated with Oenothera biennis oil, a potential therapeutic agent. Results: Our research has revealed a novel and significant likelihood of association between miR-182-5p, miR-200c-3p, miR-206-3p, miR-429-3p, miR-1298-5p, and diseases resembling the EAE model, such as MS. This groundbreaking discovery could have profound implications in diagnosing and treating autoimmune diseases that mimic the EAE animal model. Conclusions: These miRNAs, identified in our study, might serve as potential therapeutic targets in MS, potentially leading to more effective treatments and improved patient outcomes.