Low levels of soluble low-density lipoprotein receptor-related protein 1 in patients with type 2 diabetes mellitus and diabetic retinopathy

BATU OTO B., AYKUT V., Gunes M., Korkmaz R., Isman F. K., AĞIRBAŞLI M. A.

EXPERIMENTAL EYE RESEARCH, vol.215, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 215
  • Publication Date: 2022
  • Doi Number: 10.1016/j.exer.2022.108921
  • Journal Name: EXPERIMENTAL EYE RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Keywords: Diabetic retinopathy, sLRP-1, Biomarker, Serum lipids, Serum LRP-1, APOLIPOPROTEIN-E, ALPHA(2)-MACROGLOBULIN, BIOMARKER, LRP1, BETA, SLRP1, EYES
  • Istanbul University Affiliated: No

Abstract

Low-density lipoprotein receptor-related protein-1 (LRP-1) is a large transmembrane receptor. LRP-1 plays a role in diverse cellular processes, including lipid metabolism, cell growth, migration, and regeneration. Soluble form of LRP-1 (sLRP-1) can be detected in serum. sLRP-1 can serve as a biomarker of atherosclerosis and cardiometabolic diseases. This study investigated the concentrations of the circulating serum sLRP-1 in patients with retinopathy and type 2 diabetes mellitus.