Cognitive Impairment In Relapsing-Remitting Multiple Sclerosis


Topcular B. , Ozcan M. E. , Kurt E. , Kuscu D. Y. , Icen N. K. , Sutlas P. N. , et al.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.49, ss.178-182, 2012 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 49 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.4274/npa.y6089
  • Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Sayfa Sayısı: ss.178-182

Özet

Amaç: Relapsing Remitting Multipl Skleroz (RRMS) hastalar›nda Brief Repeatable
Battery (BRB) ile kognitif durum tayini yap›larak kognitif bozuklu€un s›kl›€›n›n
de€erlendirmesi, kognitif bozukluk ile ili?kili demografik ve klinik parametrelerin
incelenmesi ve kognitif bozukluk ile fiziksel özürlülük ve ya?am kalitesinin ili?kisinin
de€erlendirilmesi.
 
Yöntem: Hastanemiz Multipl Skleroz ve Demiyelinizan Hastal›klar poliklini€ine
Mart-May›s 2010 tarihleri aras›nda ba?vuran hastalar BRB, Multiple Sclerosis
Neuropsychological Questionnairre (MSNQ), Beck depresyon envanteri (BDI),
Functional Assessment of MS (FAMS) ya?am kalitesi ölçe€i ile de€erlendirildiler. 
 
Bulgular: Çal›?ma kriterlerine uygun toplam 51 hasta saptand›. Çal›?ma grubunun
ortalama skorlar› PASAT 42,76±30,41; 10/36 uzamsal hat›rlama testi k›sa süreli bellek
(KSB) 18,4±6,2, uzun süreli bellek (USB) 6,8±3,2; sözel bellek testi KSB 5,67±2,00,
USB 4,67±2,00; sembol say› modalitesi testi 29,84±19,50; sözel ak›c›l›k testi
14,14±5,74’tü. MSNQ hasta formu skor ortalamas› 10,27±11,95; Beck depresyon
envanteri skoru ortalamas› 20,20±12,17; FAMS skorlar› ortalamas› 64,18±46,52’ydi.
Olgular›n %41,17'sinde kognitif bozukluk tespit edildi. Ya?, e€itim süresi, EDSS
kognitif bozukluk ile ili?kiliyken (s›ras›yla p< 0,01; p<0,05; p<0,01), cinsiyet ve hastal›k
süresiyle kognitif bozukluk aras›nda anlaml› ili?ki saptanmad› (p>0,05; p>0,05)).
Kognitif bozuklu€u olan olgularda depresyon skorlar› daha yüksek (p<0,01) ve
ya?am kalitesi skorlar› daha kötüydü (p<0,01). 
 
Sonuç: Kogntitif bozukluk RRMS hastalar›nda s›k kar?›la?›lan bir sorundur ve
ya?am kalitesi üzerinde önemli rol oynamaktad›r. (Nöropsikiyatri Arşivi 2012; 
49: 178-182)
 
Anahtar kelimeler: Multipl skleroz, kognitif bozukluk, nöropsikoloji

Objective: To assess the frequency of cognitive impairment in patients with relapsing-remitting multiple sclerosis (RRMS) using the Brief Repeatable Battery (BRB), as well as to explore the associations of cognitive impairment with demographic and clinical parameters and to evaluate its relation with physical impairment and quality of life. 

Methods: Patients admitted to our hospital's Multiple Sclerosis and Demyelinating Diseases Outpatients Clinic between March and May 2010 were assessed using the BRB, Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), Beck depression inventory (BDI), and the Functional Assessment of MS Quality of Life Instrument (FAMS). 

Results: Fifty-one patients fulfilled the study criteria. Mean test scores of the study group were PASAT 42.76 +/- 30.41; 10/36 Spatial Recall Test (SPART)-Total Learning (TL) 18.4 +/- 6.2; delayed recall (DR) 6.8 +/- 3.2; Selective Reminding Test (SRT)-TL 5.67 +/- 2.00; SRT-DR 4.67 +/- 2.00; Symbol-Digit Modalities Test (SDMT) 29.84 +/- 19.50; Word List Generation (WLG) 14.14 +/- 5.74. The mean score of MSNQ patient form was 10.27 +/- 11.95; BDI mean score was 20.20 +/- 12.17; FAMS mean score was 64.18 +/- 46.52. 41.17% of patients had cognitive impairment. Age, education level, and EDSS scores correlated with cognitive impairment (p<0.01; p<0.05; p<0,01 respectively). There was no correlation between cognitive impairment and either gender or disease duration (p>0.05; p>0.05, respectively). Patients with cognitive impairment had higher depression scores (p<0.01) and lower quality of life scores (p<0.01). 

Discussion: Cognitive impairment is a common problem in RRMS patients and plays a major role in the quality of life. (Archives of Neuropsychiatry 2012; 49: 178-182)