Building a network of ADPKD reference centres across Europe: the EuroCYST initiative

Petzold K., Gansevoort R. T., Ong A. C. M., Devuyst O., Rotar L., Eckardt K., ...Daha Fazla

NEPHROLOGY DIALYSIS TRANSPLANTATION, cilt.29, ss.26-32, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1093/ndt/gfu091
  • Dergi Adı: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.26-32
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background. Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic inherited kidney disease, affecting an estimated 600 000 individuals in Europe. The disease is characterized by age-dependent development of a multiple cysts in the kidneys, ultimately leading to end-stage renal failure and the need of renal replacement therapy in the majority of patients, typically by the fifth or sixth decade of life. The variable disease course, even within the same family, remains largely unexplained. Similarly, assessing disease severity and prognosis in an individual with ADPKD remains difficult. Epidemiological studies are limited due to the fragmentation of ADPKD research in Europe.