Building a network of ADPKD reference centres across Europe: the EuroCYST initiative

Petzold K., Gansevoort R. T., Ong A. C. M., Devuyst O., Rotar L., Eckardt K., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.29, pp.26-32, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29
  • Publication Date: 2014
  • Doi Number: 10.1093/ndt/gfu091
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.26-32
  • Istanbul University Affiliated: Yes


Background. Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic inherited kidney disease, affecting an estimated 600 000 individuals in Europe. The disease is characterized by age-dependent development of a multiple cysts in the kidneys, ultimately leading to end-stage renal failure and the need of renal replacement therapy in the majority of patients, typically by the fifth or sixth decade of life. The variable disease course, even within the same family, remains largely unexplained. Similarly, assessing disease severity and prognosis in an individual with ADPKD remains difficult. Epidemiological studies are limited due to the fragmentation of ADPKD research in Europe.