Vitamin D Receptor (VDR) Polymorphisms in Pediatric Patients Presenting With Hodgkin's Lymphoma

Tekgunduz S. A., Yesil S., Oren A. C., Tanyildiz H. G., Candir M. O., Bozkurt C., ...Daha Fazla

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.39, sa.2, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1097/mph.0000000000000664
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: vitamin D receptor, Hodgkin's lymphoma, polymorphisms, GENE POLYMORPHISMS, TAQI POLYMORPHISMS, CANCER, METAANALYSIS, RISK, SUSCEPTIBILITY, FOKI, APAI, BSMI, VARIANTS
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Vitamin D receptor (VDR) polymorphisms are found more commonly in some tumor types than in healthy individuals, suggesting that some polymorphisms (Cdx2, Fok1, Bsm1, Apa1, Taq1) contribute to tumor development. There is no previous report on VDR polymorphism in Hodgkin's lymphoma (HL) patients. VDR polymorphism patterns in 95 pediatric HL cases with 100 healthy controls were compared. No statistically significant difference was found between the patient group and control group in terms of Cdx2, Fok1, Bsm1, Apa1, and Taq1 polymorphisms (P > 0.5). Our findings suggest that VDR polymorphisms may not play a role in HL development.