Vitamin D Receptor (VDR) Polymorphisms in Pediatric Patients Presenting With Hodgkin's Lymphoma


Tekgunduz S. A. , Yesil S., Oren A. C. , Tanyildiz H. G. , Candir M. O. , Bozkurt C., ...More

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.39, no.2, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1097/mph.0000000000000664
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: vitamin D receptor, Hodgkin's lymphoma, polymorphisms, GENE POLYMORPHISMS, TAQI POLYMORPHISMS, CANCER, METAANALYSIS, RISK, SUSCEPTIBILITY, FOKI, APAI, BSMI, VARIANTS

Abstract

Vitamin D receptor (VDR) polymorphisms are found more commonly in some tumor types than in healthy individuals, suggesting that some polymorphisms (Cdx2, Fok1, Bsm1, Apa1, Taq1) contribute to tumor development. There is no previous report on VDR polymorphism in Hodgkin's lymphoma (HL) patients. VDR polymorphism patterns in 95 pediatric HL cases with 100 healthy controls were compared. No statistically significant difference was found between the patient group and control group in terms of Cdx2, Fok1, Bsm1, Apa1, and Taq1 polymorphisms (P > 0.5). Our findings suggest that VDR polymorphisms may not play a role in HL development.