Silver nanoparticle/capecitabine for breast cancer cell treatment.

Hepokur, C; Karıper, İa; Mısır, S; Ay, E; Tunoğlu, S; Ersez, Mediha; Zeybek, Şakir; Kuruca, Dürdane; Yaylım, İlhan

doi:10.1016/j.tiv.2019.104600

Silver nanoparticle/capecitabine for breast cancer cell treatment.

Hepokur C., Karıper İ., Mısır S., Ay E., Tunoğlu S., Ersez M., ...Daha Fazla

Toxicology in vitro : an international journal published in association with BIBRA, cilt.61, ss.104600, 2019 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 61
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.tiv.2019.104600
Dergi Adı: Toxicology in vitro : an international journal published in association with BIBRA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.104600
Anahtar Kelimeler: Breast cancer (MCF-7), Capecitabine, Silver nanoparticles, Apoptosis, MEDIATED SYNTHESIS, NANOPARTICLES, CYTOTOXICITY
İstanbul Üniversitesi Adresli: Evet

Özet

© 2019This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.