Silver nanoparticle/capecitabine for breast cancer cell treatment


Hepokur C., Karıper İ., Mısır S., Ay E., Tunoğlu S., Ersez M. , ...Daha Fazla

Toxicology in Vitro, cilt.61, 2019 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

Özet

© 2019This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.