The effect of heme oxygenase-1 induction by glutamine on radiation-induced intestinal damage: the effect of heme oxygenase-1 on radiation enteritis

Giris M., Erbil Y., Oztezcan S., Olgac V., Barbaros U., Deveci U., ...More

AMERICAN JOURNAL OF SURGERY, vol.191, no.4, pp.503-509, 2006 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 191 Issue: 4
  • Publication Date: 2006
  • Doi Number: 10.1016/j.amjsurg.2005.11.004
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.503-509


Background: Radiation enteritis is a significant clinical problem in patients receiving ionizing radiation directed at the abdomen or pelvis. The small intestine is the most radiosensitive gastrointestinal organ. Myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels of the small intestine were measured to determine the oxidative damage caused by radiation. In addition, caspase-3 activity of the small intestine was measured to define the degree of apoptosis. The present study was undertaken to investigate the effect of glutamine administration on heme oxygenase-1 (HO-1) expression of the radiation enteritis model.