The combination of nterleukin-10-1082 and tumor necrosis factor alpha-308 or interleukin-6-174 genes polymorphisms suggests an association with susceptibility to Hashimoto's thyroiditis

Baki M., Akman F. E., Vural P., Dogru-Abbasoglu S., OZDERYA A., KARADAG B., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.12, no.4, pp.543-546, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1016/j.intimp.2012.02.003
  • Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.543-546
  • Istanbul University Affiliated: Yes

Abstract

Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) has not been clearly elucidated although the role of chronical inflammation and endothelial dysfunction has been established. The imbalance between pro- and anti-inflammatory cytokines may play a role in the etiology. The aim of the present study was to investigate whether cytokine gene polymorphisms are associated with HT, and to evaluate the relationship between genotypes and clinical/laboratory manifestation of HT.