The combination of nterleukin-10-1082 and tumor necrosis factor alpha-308 or interleukin-6-174 genes polymorphisms suggests an association with susceptibility to Hashimoto's thyroiditis

Baki M. , Akman F. E. , Vural P. , Dogru-Abbasoglu S. , OZDERYA A., KARADAG B., ...Daha Fazla

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.12, ss.543-546, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 12 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.intimp.2012.02.003
  • Sayfa Sayıları: ss.543-546


Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) has not been clearly elucidated although the role of chronical inflammation and endothelial dysfunction has been established. The imbalance between pro- and anti-inflammatory cytokines may play a role in the etiology. The aim of the present study was to investigate whether cytokine gene polymorphisms are associated with HT, and to evaluate the relationship between genotypes and clinical/laboratory manifestation of HT.