Vagus nerve stimulation inhibits seizure activity and protects blood-brain barrier integrity in kindled rats with cortical dysplasia

Kaya, Mehmet; Orhan, Nurcan; Karabacak, Emrah; Bahceci, Metin; Arican, Nadir; Ahishali, Bülent; Kemikler, Gönül; Uslu, Atilla; Cevik, Aydın; Yilmaz, Canan; Kucuk, Mutlu; Gurses, Candan

doi:10.1016/j.lfs.2013.01.009

Vagus nerve stimulation inhibits seizure activity and protects blood-brain barrier integrity in kindled rats with cortical dysplasia

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Kaya M., Orhan N., Karabacak E., Bahceci M. B., Arican N., Ahishali B., ...More

LIFE SCIENCES, vol.92, pp.289-297, 2013 (SCI-Expanded)

Publication Type: Article / Article
Volume: 92
Publication Date: 2013
Doi Number: 10.1016/j.lfs.2013.01.009
Journal Name: LIFE SCIENCES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.289-297
Keywords: Cortical dysplasia, Vagus nerve stimulation, Blood-brain barrier, TUBEROUS SCLEROSIS, P-GLYCOPROTEIN, REFRACTORY EPILEPSY, ANIMAL-MODELS, MALFORMATIONS, EPILEPTOGENESIS, EXPRESSION, PHARMACORESISTANCE, NOREPINEPHRINE, HIPPOCAMPUS
Istanbul University Affiliated: Yes

Abstract

Aims: This study investigates the effects of vagus nerve stimulation (VNS) on seizure severity and blood-brain barrier (BBB) integrity in kindled rats with cortical dysplasia (CD).