Vagus nerve stimulation inhibits seizure activity and protects blood-brain barrier integrity in kindled rats with cortical dysplasia

Kaya, Mehmet; Orhan, Nurcan; Karabacak, Emrah; Bahceci, Metin; Arican, Nadir; Ahishali, Bülent; Kemikler, Gönül; Uslu, Atilla; Cevik, Aydın; Yilmaz, Canan; Kucuk, Mutlu; Gurses, Candan

doi:10.1016/j.lfs.2013.01.009

Vagus nerve stimulation inhibits seizure activity and protects blood-brain barrier integrity in kindled rats with cortical dysplasia

Kaya M., Orhan N., Karabacak E., Bahceci M. B., Arican N., Ahishali B., ...Daha Fazla

LIFE SCIENCES, cilt.92, ss.289-297, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 92
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.lfs.2013.01.009
Dergi Adı: LIFE SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.289-297
Anahtar Kelimeler: Cortical dysplasia, Vagus nerve stimulation, Blood-brain barrier, TUBEROUS SCLEROSIS, P-GLYCOPROTEIN, REFRACTORY EPILEPSY, ANIMAL-MODELS, MALFORMATIONS, EPILEPTOGENESIS, EXPRESSION, PHARMACORESISTANCE, NOREPINEPHRINE, HIPPOCAMPUS
İstanbul Üniversitesi Adresli: Evet

Özet

Aims: This study investigates the effects of vagus nerve stimulation (VNS) on seizure severity and blood-brain barrier (BBB) integrity in kindled rats with cortical dysplasia (CD).