Vagus nerve stimulation inhibits seizure activity and protects blood-brain barrier integrity in kindled rats with cortical dysplasia


Kaya M., Orhan N., Karabacak E., Bahceci M. B., Arican N., Ahishali B., ...More

LIFE SCIENCES, vol.92, pp.289-297, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92
  • Publication Date: 2013
  • Doi Number: 10.1016/j.lfs.2013.01.009
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.289-297
  • Keywords: Cortical dysplasia, Vagus nerve stimulation, Blood-brain barrier, TUBEROUS SCLEROSIS, P-GLYCOPROTEIN, REFRACTORY EPILEPSY, ANIMAL-MODELS, MALFORMATIONS, EPILEPTOGENESIS, EXPRESSION, PHARMACORESISTANCE, NOREPINEPHRINE, HIPPOCAMPUS
  • Istanbul University Affiliated: Yes

Abstract

Aims: This study investigates the effects of vagus nerve stimulation (VNS) on seizure severity and blood-brain barrier (BBB) integrity in kindled rats with cortical dysplasia (CD).