Neuropathic pain

BEBEK N., Ertas M.

AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY, cilt.19, sa.3, ss.5-10, 2007 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: AGRI-THE JOURNAL OF THE TURKISH SOCIETY OF ALGOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.5-10
  • İstanbul Üniversitesi Adresli: Evet

Özet

Neuropathic pain is caused by functional abnormalities of structural lesions or dysfunction in the peripheral or central nervous system, and occurs without peripheral nociceptor stimulation. Neuropathic pain has a great impact on the quality of life. Majority of the patients are unable to maintain an independent lifestyle due to their moderate to severe chronic pain and often depression contributes to the illness. Many common diseases, such as stroke, multiple sclerosis and syringomyelia may produce neuropathic pain. Neuropathic pain is a complex disease, involving several molecular pathways. Neuropathic pain treatment is stil extremely difficult despite our knowledge about this difficult to diagnose and treat pain condition has improved a lot with the aid of recent experimental and clinical studies. This review summarizes the underlying mechanisms, diagnosis and treatment approaches based on different mechanisms of effect.