Intercellular Adhesion Molecule-1 Lys469Glu Polymorphism, Systemic Redox Homeostasis and Gestational Diabetes Mellitus in Pregnant Women


Yanar K., Aydin S., Simsek B., Yaylim I. , Turan S., Sitar M. E. , ...Daha Fazla

CANADIAN JOURNAL OF DIABETES, cilt.43, ss.173-179, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 43 Konu: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jcjd.2018.07.003
  • Dergi Adı: CANADIAN JOURNAL OF DIABETES
  • Sayfa Sayıları: ss.173-179

Özet

Objectives: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in endothelial function. Hyperglycemia-induced impaired redox status is 1 of the well-known pathophysiologic characteristics of gestational diabetes mellitus (GDM), and it plays a crucial role in the causes of disease. Our aim was to clarify any possible relationship between the ICAM-1 Lys469Glu polymorphism and systemic redox status in women with and without GDM. Also, we investigated whether this polymorphism could be associated with a change for better or worse as evidenced by clinical and redox biomarkers.