Intercellular Adhesion Molecule-1 Lys469Glu Polymorphism, Systemic Redox Homeostasis and Gestational Diabetes Mellitus in Pregnant Women

Yanar K., Aydin S., Simsek B., Yaylim I., Turan S., Sitar M. E., ...More

CANADIAN JOURNAL OF DIABETES, vol.43, no.3, pp.173-179, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jcjd.2018.07.003
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.173-179
  • Keywords: antioxidants, gestational diabetes mellitus, intercellular adhesion molecule-1, lipid peroxidation, Lys469Glu polymorphism, redox homeostasis, OXIDATIVE STRESS, K469E POLYMORPHISM, ASSOCIATION, RETINOPATHY, PRODUCTS, DAMAGE, TESTS, IRON
  • Istanbul University Affiliated: Yes


Objectives: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in endothelial function. Hyperglycemia-induced impaired redox status is 1 of the well-known pathophysiologic characteristics of gestational diabetes mellitus (GDM), and it plays a crucial role in the causes of disease. Our aim was to clarify any possible relationship between the ICAM-1 Lys469Glu polymorphism and systemic redox status in women with and without GDM. Also, we investigated whether this polymorphism could be associated with a change for better or worse as evidenced by clinical and redox biomarkers.