Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock
Anesthesiology, cilt.131, ss.1110-1124, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 131
- Basım Tarihi: 2019
- Doi Numarası: 10.1097/aln.0000000000002932
- Dergi Adı: Anesthesiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1110-1124
- İstanbul Üniversitesi Adresli: Evet
Özet
Background: Primary resuscitation fluid to treat hemorrhagic shock remains controversial. Use of hydroxyethyl starches raised concerns of acute kidney injury. Polyethylene-glycolated carboxyhemoglobin, which has carbon monoxide-releasing molecules and oxygen-carrying properties, was hypothesized to sustain cortical renal microcirculatory Po-2 after hemorrhagic shock and reduce kidney injury.