Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock


Guerci P., Ergin B., Kapucu A. , Hilty M. P. , Jubin R., Bakker J., ...Daha Fazla

Anesthesiology, cilt.131, ss.1110-1124, 2019 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 131
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1097/aln.0000000000002932
  • Dergi Adı: Anesthesiology
  • Sayfa Sayıları: ss.1110-1124

Özet

Background: Primary resuscitation fluid to treat hemorrhagic shock remains controversial. Use of hydroxyethyl starches raised concerns of acute kidney injury. Polyethylene-glycolated carboxyhemoglobin, which has carbon monoxide-releasing molecules and oxygen-carrying properties, was hypothesized to sustain cortical renal microcirculatory Po-2 after hemorrhagic shock and reduce kidney injury.