Effect of polyethylene-glycolated carboxyhemoglobin on renal microcirculation in a rat model of hemorrhagic shock

Guerci P., Ergin B., Kapucu A., Hilty M. P., Jubin R., Bakker J., ...Daha Fazla

Anesthesiology, cilt.131, ss.1110-1124, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 131
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1097/aln.0000000000002932
  • Dergi Adı: Anesthesiology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1110-1124
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Primary resuscitation fluid to treat hemorrhagic shock remains controversial. Use of hydroxyethyl starches raised concerns of acute kidney injury. Polyethylene-glycolated carboxyhemoglobin, which has carbon monoxide-releasing molecules and oxygen-carrying properties, was hypothesized to sustain cortical renal microcirculatory Po-2 after hemorrhagic shock and reduce kidney injury.