Synthesis and biological activity of new 1,3-dioxolanes as potential antibacterial and antifungal compounds


Başpınar Küçük H. , Yusufoğlu A. S. , Mataracı E. , Döşler S.

Molecules, vol.16, pp.6806-6815, 2011 (Journal Indexed in SCI)

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2011
  • Title of Journal : Molecules
  • Page Numbers: pp.6806-6815

Abstract

A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.