Comparison of Ischemic Preconditioning and Systemic Piracetam for Prevention of Ischemia-Reperfusion Injury in Musculocutaneous Flaps

DEMİRÖZ A., DEREBAŞINLIOĞLU H., Ercan A., ARSLAN H., Aydin O., EKMEKÇİ H., ...More

JOURNAL OF RECONSTRUCTIVE MICROSURGERY, vol.37, no.4, pp.322-335, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1055/s-0040-1716822
  • Journal Name: JOURNAL OF RECONSTRUCTIVE MICROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.322-335
  • Keywords: Ischemia-Reperfusion injury, latissimus dorsi, microvascular free flap operations, piracetam
  • Istanbul University Affiliated: Yes

Abstract

Background Ischemia-reperfusion injury plays an important role in flap failure. Ischemic preconditioning technique is the only proven method for preventing ischemia-reperfusion injury, but it is not used widely in daily practice because of difficulties such as prolonging the operation time, need for surgical experience, and increasing the risk of complications. This study has been performed with the assumption that piracetam may be a simple and inexpensive alternative to the preconditioning technique due to its antioxidant, antiaggregant, rheological, anti-inflammatory, antiapoptotic, cytoprotective, and immune modulating effects.