Cytokine Contents in Chronic Lymphocytic Leukemia: Association with ZAP70 Expression

Isiksacan N., Cinar S., Cetin E., Aktan M., Deniz G.

TURKISH JOURNAL OF HEMATOLOGY, cilt.33, sa.3, ss.202-208, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4274/tjh.2014.0469
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.202-208
  • Anahtar Kelimeler: ZAP70, Interleukin-4, Interferon gamma, T cells, B cells, Chronic lymphocytic leukemia, GENE MUTATION STATUS, V-H GENES, ZAP-70 EXPRESSION, PROGNOSTIC INDICATORS, DISEASE PROGRESSION, CD38 EXPRESSION, FLOW-CYTOMETRY, B-CLL, DIAGNOSIS, CELLS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Chronic lymphocytic leukemia (CLL) is a disease that shows varying clinical progression, and expression of the protein tyrosine kinase ZAP70 has been described as a very valuable prognostic factor. Patients with ZAP70 positivity are characterized by worse clinical course and significantly shorter progression-free and overall survival. In this study, intracytoplasmic interferon gamma (IFN-gamma) and interleukin-4 (IL-4) content of T, B, and CLL cells in CLL patients and their correlations with Rai staging and ZAP70 positivity were investigated.