Cytokine Contents in Chronic Lymphocytic Leukemia: Association with ZAP70 Expression


Isiksacan N., Cinar S., Cetin E., Aktan M., Deniz G.

TURKISH JOURNAL OF HEMATOLOGY, vol.33, no.3, pp.202-208, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.4274/tjh.2014.0469
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.202-208
  • Keywords: ZAP70, Interleukin-4, Interferon gamma, T cells, B cells, Chronic lymphocytic leukemia, GENE MUTATION STATUS, V-H GENES, ZAP-70 EXPRESSION, PROGNOSTIC INDICATORS, DISEASE PROGRESSION, CD38 EXPRESSION, FLOW-CYTOMETRY, B-CLL, DIAGNOSIS, CELLS

Abstract

Objective: Chronic lymphocytic leukemia (CLL) is a disease that shows varying clinical progression, and expression of the protein tyrosine kinase ZAP70 has been described as a very valuable prognostic factor. Patients with ZAP70 positivity are characterized by worse clinical course and significantly shorter progression-free and overall survival. In this study, intracytoplasmic interferon gamma (IFN-gamma) and interleukin-4 (IL-4) content of T, B, and CLL cells in CLL patients and their correlations with Rai staging and ZAP70 positivity were investigated.