Vaccination coverage of children with rheumatic diseases compared with healthy controls: a retrospective case-control study.


Akgün Ö., Demirkan F. G., Kavrul Kayaalp G., Erdemir M., Akay N., Çakmak F., ...Daha Fazla

Postgraduate medicine, cilt.135, sa.8, ss.824-830, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 135 Sayı: 8
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/00325481.2023.2287988
  • Dergi Adı: Postgraduate medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EBSCO Education Source, Educational research abstracts (ERA), International Pharmaceutical Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.824-830
  • Anahtar Kelimeler: children, incomplete vaccine, missing vaccine, rheumatic disease, Vaccination coverage
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: To reveal the vaccination status of patients with pediatric rheumatic disease (PedRD) and to compare this with healthy controls.Methods: The electronic health records of the Ministry of Health regarding the vaccination status of children with PedRD followed in a tertiary hospital were analyzed cross-sectionally and compared with their healthy controls. The missing vaccines were reported according to individual, age-appropriate schedule and causes of skipped vaccines in both groups were investigated with an online survey.Results: The vaccination rate of patients in the last examination was 71.4% (90/126) and 95.7% (110/115) in healthy controls (p < 0.001). Measles-mumps-rubella vaccine, diphtheria, the administration rates of the second dose of tetanus-acellular pertussis-inactivated polio and Haemophilus influenzae type B, chickenpox, and hepatitis A vaccines were significantly lower in patients than in controls (p values 0.004, 0.02, 0.01, 0.013, respectively). The pre-diagnosis incomplete vaccination proportion was significantly higher in the patient group (16.6%) than in healthy controls (4.3%) (p = 0.002). In the patient group, the proportion of incomplete live-attenuated vaccines after diagnosis (25%) was more than pre-diagnosis (61.1%) (p = 0.04), while the proportion of incomplete non-live vaccines before and after diagnosis was similar (47.2% and 50%, respectively) (p = 0.73). The major reasons for missed vaccines were physicians' recommendations (15.6%), the presence of PedRD diagnosis (12.5%), and the drugs used (12.5%).Conclusion: Vaccination coverage of PedRD patients has been shown to lag behind the routine vaccination schedule (71.4%). In addition to new recommendations, electronic health system records for vaccination may be appropriate for the follow-up of these patients, and the addition of reminder alerts may be useful to reduce the rate of missed vaccinations.