Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease


DEMIRKAYA E., Zhou Q., Smith C. K., Ombrello M. J., Deuitch N., Tsai W. L., ...More

ARTHRITIS & RHEUMATOLOGY, vol.69, no.9, pp.1832-1839, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 9
  • Publication Date: 2017
  • Doi Number: 10.1002/art.40158
  • Journal Name: ARTHRITIS & RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1832-1839
  • Istanbul University Affiliated: Yes

Abstract

Objective. To identify a genetic cause of early-onset systemic lupus erythematosus (SLE) in a large consanguineous family from Turkey and to study the mechanisms of the disease.