Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease

DEMIRKAYA, Erkan; Zhou, Qing; Smith, Carolyne; Ombrello, Michael; Deuitch, Natalie; Tsai, Wanxia; Hoffmann, Patrycja; Remmers, Elaine; TAKEUCHI, Masaki; Park, Yong; CHAE, JaeJin; Barut, Kenan; SIMSEK, Dogan; Adrovic, Amra; Sahin, Sezgin; Caliskan, Salim; CHANDRASEKHARAPPA, Settara; HASNI, Sarfaraz; OMBRELLO, Amanda; GADINA, Massimo; KASTNER, Daniel; KAPLAN, Mariana; Kasapcopur, Özgür; AKSENTIJEVICH, Ivona

doi:10.1002/art.40158

Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease

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DEMIRKAYA E., Zhou Q., Smith C. K., Ombrello M. J., Deuitch N., Tsai W. L., ...More

ARTHRITIS & RHEUMATOLOGY, vol.69, no.9, pp.1832-1839, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 69 Issue: 9
Publication Date: 2017
Doi Number: 10.1002/art.40158
Journal Name: ARTHRITIS & RHEUMATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1832-1839
Istanbul University Affiliated: Yes

Abstract

Objective. To identify a genetic cause of early-onset systemic lupus erythematosus (SLE) in a large consanguineous family from Turkey and to study the mechanisms of the disease.