Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity


Demir M. G. , ALTINTOPRAK N., Aydin S., Kosemihal E., BASAK K.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.11, no.3, pp.202-206, 2015 (SCI-Expanded) identifier identifier identifier

Abstract

OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity.