Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity


Demir M. G. , ALTINTOPRAK N., Aydin S. , Kosemihal E., BASAK K.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, cilt.11, ss.202-206, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/iao.2015.1084
  • Dergi Adı: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Sayfa Sayıları: ss.202-206

Özet

OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity.